Better computer ranking of medicine pairs for DIPG
- Good it would do
- 5 / 5
- Can AI help
- 3 / 5
- How neglected
- 4 / 5
- Can we check it
- 3 / 5
Why it's stuck
A 2020 repurposing study found only moderate agreement between computer predictions and lab results, and blamed weak brain-permeability modeling and bias in the literature it learned from. Few groups have followed up.
What we'd try
Redo the search with better permeability models and patient-derived data, then hand a ranked list to lab partners.
What could stop us
Several computational DIPG repurposing pipelines already exist, and checking a new ranking needs lab data the lab may not have.
Source: https://www.biorxiv.org/content/10.1101/2020.06.14.150714v3.full
Do you know the answer?
One reply from someone in the field can settle what our AI can't.